Private investigators are looking into 30 new reported sightings of Madeleine McCann, Sky News reported.
The calls came after her parents appeared on Oprah Winfrey's talk show to mark the two year anniversary of her disappearance.
There have also been thousands of new hits on the Find Madeleine Web site.
"All of the calls are being checked out and where there is a shred of hope they are being investigated," said McCann spokesman, Clarence Mitchell.
Two former British detectives are now working for the campaign and will be handling the new information.
It's thought the potential sightings were made in North and South America as well as a handful in Europe.
Kate and Gerry McCann flew to the U.S. to publicise the second anniversary of Madeleine's disappearance.
They also visited The National Centre for Missing and Exploited Children in Washington, where experts created a new image of Madeleine at age 6.
Source: Fox News and Metro.co.uk
New suspect in the hunt for Madeleine
By FRED ATTEWILL - Wednesday, May 6, 2009
An artist's impression has been released of a new suspect in the continuing hunt for missing Madeleine McCann.
'These are vital areas that have been just sitting in the files and we need to release them,' said Clarence Mitchell, spokesman for the McCanns.
The new image coincides with a Channel 4 documentary tonight, which follows the McCanns, from Rothley in Leicestershire, and the work of two retired British police officers hired by them to continue the search.
Madeleine, who would turn six on Tuesday, disappeared from the Portuguese resort of Praia da Luz on May 3, 2007. But four days earlier, the unnamed tourist was out with her daughter when she saw the suspect 'acting suspiciously'.
She saw the man again outside the flat the day before Madeleine went missing. She told police he was about 1.77m (5ft 10in), slim and was wearing casual clothes, probably jeans.
Another two witnesses - a 12-year-old girl and a man from Cheshire - also reported seeing a man watching the flat in the days before Madeleine vanished.
Tonight's programme features reconstructions of these sightings, as well as those of Jane Tanner, one of the 'Tapas Seven', and Irish tourist Martin Smith.
They both saw a man carrying a young child near the flat around the time of the disappearance.